Full-Spectrum Hemp Gummy Products – Mechanisms & Evidence Cheat Sheet

Get Up Stand Up (CBDA + CBGA Formula)

• Key Ingredients (Dosage): Each vegan gummy delivers 5 mg CBDA (cannabidiolic acid) and 5 mg CBGA (cannabigerolic acid). This is a THC-free, raw (unheated) 1:1 CBDA:CBGA formulation with no Δ⁹-THC present.

• Mechanisms of Action:

  • CBDA (Cannabidiolic Acid): The unheated precursor to CBD. Selective COX-2 inhibitor – CBDA potently blocks the inflammatory COX-2 enzyme (~9× selectivity over COX-1)pubmed.ncbi.nlm.nih.gov, which can reduce prostaglandin-mediated inflammation. CBDA also activates 5-HT₁A serotonin receptors, a mechanism linked to anti-nausea and anxiolytic effects (CBDA is more potent than CBD at reducing nausea via 5-HT₁A activation)pmc.ncbi.nlm.nih.gov.

  • CBGA (Cannabigerolic Acid): The “mother cannabinoid” from which others derive. Anti-inflammatory & cytoprotective: CBGA has been shown to suppress pro-inflammatory cytokines in preclinical models (e.g. reducing IL-6 in an acute inflammation study)pmc.ncbi.nlm.nih.gov. It also interacts with cellular targets like TRP channels (CBGA uniquely inhibits the TRPM7 channel involved in magnesium balance)pmc.ncbi.nlm.nih.gov and can activate PPARα/γ nuclear receptorssciencedirect.com, which may support metabolic health and energy homeostasis. CBGA’s broad activity contributes to reduced inflammation and potential immune-modulating effects.

• Evidence-Based Benefits:

  • Immune Support & Anti-Inflammatory: By inhibiting COX-2 and inflammatory cytokines, the CBDA+CBGA combination can reduce inflammation and support immune functionpubmed.ncbi.nlm.nih.govpmc.ncbi.nlm.nih.gov. (Notably, CBDA’s selective COX-2 inhibition may resemble the action of NSAIDs, helping to relieve inflammatory aches and soreness.)

  • Energy & Vitality (Jitter-Free): This formula is non-psychoactive and won’t cause sedation. In fact, reducing inflammation and pain can improve energy levels. CBGA’s activation of PPAR pathways and other metabolic targets is thought to enhance mitochondrial function and energy metabolismsciencedirect.com, providing a subtle boost in alertness without caffeine-like jitters.

  • Pain Relief (Aches & Soreness): Both acidic cannabinoids exhibit analgesic properties. CBDA’s COX-2 blockade lowers inflammatory pain signalingpubmed.ncbi.nlm.nih.gov, while CBGA’s anti-inflammatory and neuroprotective effects may help with neuropathic and muscle painpmc.ncbi.nlm.nih.gov. The dual action addresses pain at the inflammatory source, which can alleviate post-exercise soreness or chronic aches.

  • Stress Reduction: Anxiolytic effects without impairment – CBDA indirectly activates serotonin 5-HT₁A receptors (similar mechanism as certain anti-anxiety medications)pmc.ncbi.nlm.nih.gov, which can reduce stress and worry. Users may experience a calmer mindset and reduced “fight-or-flight” feelings, all with no THC, so there is no intoxication or anxiety from psychoactive cannabinoids.

• Delivery & Formulation: Tangerine-flavored pectin gummy (plant-based, vegan formulation). Made with organic tapioca syrup and cane sugar (no corn syrup, no artificial sweeteners). Contains full-spectrum hemp extract from U.S.-grown hemp, retaining minor cannabinoids and terpenes (but 0% Δ⁹-THC). No artificial cannabinoids are added – the acidic cannabinoids are naturally derived from hemp and preserved by avoiding heat. Third-party lab tested for purity and potency (ISO-certified lab results available) to ensure quality and compliance.

Nightcap (Full-Spectrum Sleep Gummy: CBG + THC)

• Key Ingredients (Dosage): 10 mg CBG (cannabigerol) + 5 mg Δ⁹-THC per gummy (approx. 2:1 ratio of CBG:THC). This is a full-spectrum formula including minor cannabinoids (trace amounts of CBC, CBN, etc.) and terpenes.

• Mechanisms of Action:

  • CBG (Cannabigerol): A non-intoxicating cannabinoid known for broad receptor activity. CBG binds both CB₁ and CB₂ receptors with lower potency than THC, acting as a partial agonist/antagonist that can tone down overactive signals. It also interacts with other systems: for example, CBG may inhibit GABA reuptake, promoting muscle relaxation and calm, and can influence adrenergic and serotonin receptors (which contributes to anxiolytic and antidepressant effects in preclinical studies)pmc.ncbi.nlm.nih.govpmc.ncbi.nlm.nih.gov. Importantly for sleep, CBG is thought to prolong sleep duration in animal models and synergize with THC to deepen sedative effects (by reducing anxiety and relaxing the body).

  • Δ⁹-THC (Tetrahydrocannabinol): The primary psychoactive cannabinoid. At 5 mg, THC acts as a central nervous system depressant through CB₁ receptor agonism – promoting sedation, sleep initiation, and pain relief. THC triggers downstream release of adenosine and inhibits arousal neurotransmitters, thereby helping one fall asleep faster. It also has well-documented analgesic effects, modulating pain pathways at spinal and supraspinal levelsjpain.org. Low-to-moderate doses of THC can reduce anxiety and stress (e.g. a clinical trial showed 7.5 mg THC reduced stress responses without adverse mood effects)pubmed.ncbi.nlm.nih.gov, which further supports sleep by calming the mind.

• Evidence-Based Benefits:

  • Supports Sleep Onset & Maintenance: This gummy is designed to help you get to sleep and stay asleep. CBG is the “star” cannabinoid for promoting restful sleep – in a 2022 survey of CBG-predominant cannabis users, ~31% used CBG for insomnia or disturbed sleep, and the majority reported their sleep was “much improved” with CBGpmc.ncbi.nlm.nih.gov. THC adds a sedative push: clinical evidence shows low-dose THC shortens sleep latency and may increase deep slow-wave sleep (while higher doses can disrupt sleep architecture). Together, CBG + THC likely have complementary sedative effects: CBG alleviates stress and keeps you asleep (reducing nocturnal awakenings), while THC helps initiate sleep and enhance overall sleep depth. Users often wake up refreshed since this balanced dose is enough to sustain sleep but mild enough to avoid next-day grogginess.

  • Anxiolytic & Relaxation: Nightcap eases you into relaxation by targeting both mental and physical tension. CBG has demonstrated anxiolytic properties (in the CBG user survey, ~51% used it for anxiety and reported high efficacy)pmc.ncbi.nlm.nih.gov. Meanwhile, 5 mg THC is a low dose that can relieve anxiety and stress – consistent with human studies where THC in low amounts reduced subjective distress during stressful taskspubmed.ncbi.nlm.nih.gov. By dampening “racing thoughts” and stress responses, the formula helps quiet the mind at bedtime. Additionally, CBG’s possible GABA-enhancing effect and THC’s muscle-relaxant action work together to release physical tension, creating a calming, drowsy effect ideal for nighttime.

  • Pain Relief & Nerve Soothing: Both cannabinoids are known to help with pain, which can be crucial for improving sleep quality. CBG has anti-inflammatory effects (it can reduce inflammatory markers similar to CBDpmc.ncbi.nlm.nih.gov) and is reported to alleviate neuropathic discomfort (users in one study found CBG-rich cannabis very helpful for chronic pain)pmc.ncbi.nlm.nih.gov. THC’s analgesic action via CB₁ receptor activation can significantly reduce pain signalsjpain.org and even modulate the perception of pain in the brain (it’s been used clinically for neuropathic pain and fibromyalgia). The 2:1 CBG:THC ratio in Nightcap provides a balanced analgesic effect: THC directly reduces pain intensity, while CBG may prevent inflammation and soothe nerve firing. This can relieve aches (e.g. joint or muscle pain) that would otherwise hinder sleep.

  • Overall Synergy for Sleep: Full-spectrum synergy means that CBG + THC + minor cannabinoids work in concert. Notably, formulations with multiple cannabinoids often outperform THC alone for sleep and painliebertpub.com. For example, one review found THC by itself doesn’t significantly lower certain inflammatory cytokines, but THC combined with CBD or CBG doesliebertpub.com – indicating a more robust therapeutic effect. In Nightcap, the presence of CBG (and trace CBN/CBC) may enhance THC’s benefits while mitigating side effects. The result is a clinically grounded sleep aid that leverages the entourage effect for maximum efficacy.

• Format & Formulation: Berry-flavored full-spectrum gummy made with organic, vegan ingredients (tapioca syrup, cane sugar, fruit juice for color). No artificial flavors or corn syrup. Contains natural hemp-derived Δ⁹-THC (compliant <0.3% THC by weight) and CBG from full-spectrum hemp extract. The product is third-party lab tested to verify cannabinoid content (each gummy ~0.1% THC by weight) and ensure no pesticides/heavy metals. Recommended for adult use at night; start with one gummy (~5 mg THC) due to THC content. This formulation is physician-developed to be potent but clean – no melatonin or sedating additives, relying purely on cannabinoid science for sleep support.

Bliss (Berry Blissful Full-Spectrum Gummy: 1:1 CBD:THC)

• Key Ingredients (Dosage): 5 mg CBD (cannabidiol) + 5 mg Δ⁹-THC per gummy, in a 1:1 ratio. Also contains trace CBG (~0.14 mg) from the full-spectrum hemp extract. This even CBD:THC blend is similar in cannabinoid profile to certain medical formulations (e.g. nabiximols).

• Mechanisms of Action:

  • Δ⁹-THC: At 5 mg, THC provides a mild euphoric effect and therapeutic psychoactivity. THC binds CB₁ receptors in the brain’s reward and limbic regions, releasing dopamine and endorphins which elevate mood and can create a feeling of “bliss”imperial.ac.uk. It also activates CB₁ in the amygdala and hypothalamus, which can reduce anxiety and induce calm when dosed low. THC’s analgesic and muscle-relaxant effects (via CB₁ and CB₂ activation) contribute to an overall sense of comfort and well-being.

  • CBD: A non-intoxicating cannabinoid that modulates the endocannabinoid system and complements THC. CBD is an allosteric modulator of CB₁ receptors (dampening THC’s overactivation) and inhibits FAAH, raising levels of anandamide (an endogenous cannabinoid). It also activates 5-HT₁A serotonin receptors, conferring anxiolytic and antidepressant-like effectsthepermanentejournal.org. In essence, CBD counterbalances THC: it can reduce THC-induced anxiety or tachycardia, while adding its own anti-anxiety, anti-inflammatory, and neuroprotective properties. This balanced mechanism means the user experiences a gentle uplift in mood without intense intoxication.

  • Synergy (Entourage Effect): CBD and THC together have been shown to have synergistic benefits. CBD may prolong THC’s therapeutic window by delaying its metabolism and moderating tolerance. The 1:1 ratio is known in clinical research to provide robust pain relief and spasm reduction (each enhances the other’s analgesic and antispasmodic effects)jpain.org. Additionally, full-spectrum extracts with CBD+THC can produce greater anti-inflammatory effects than THC aloneliebertpub.com. This synergy underpins many of the product’s claims, marrying THC’s direct physiological effects with CBD’s modulating and protective influence.

• Evidence-Backed Benefits:

  • Mood Elevation & Euphoria: As the name suggests, “Bliss” provides a gentle lift in mood. Low-dose THC is clinically shown to relieve stress and elevate mood – e.g. 7.5 mg THC in a study significantly reduced subjects’ post-stress negativity and produced stress-relief comparable to what cannabis users reportpubmed.ncbi.nlm.nih.gov. Here 5 mg THC should similarly induce a positive mood state (activating reward pathways), but kept in balance by equal CBD to avoid overexcitement. Users may feel a mild euphoria and uplift about 30–60 minutes after ingestion, corresponding to THC’s dopamine releaseimperial.ac.uk. This can translate to improved outlook, sociability, and a feeling of “pleasant contentment.”

  • Anxiety & Stress Relief: CBD + THC together are effective anxiolytics. CBD on its own has been shown to reduce anxiety in clinical trials (for instance, 300–600 mg CBD markedly lowered public-speaking anxiety in patients with social anxiety disorder)thepermanentejournal.org. While our dose is smaller, the presence of THC at 5 mg can also help – importantly, low-dose THC tends to decrease anxiety whereas higher doses may increase itpubmed.ncbi.nlm.nih.gov. The combination in Bliss leverages this: THC provides immediate calm via CB1-mediated suppression of stress hormones, and CBD provides sustained anxiety relief via serotonin receptors and endocannabinoid balance. Scientific reviews note that THC paired with CBD yields anxiolytic and anti-stress effects greater than THC alone, due to CBD’s modulation of fear responsesliebertpub.com. Therefore, Bliss can be used to ease situational stress (e.g. unwinding after work or mitigating social anxiety), promoting a relaxed yet clear-headed state.

  • Emotional Balance & Focus: Beyond just elevating mood, the 1:1 formula can steady emotional swings. CBD has anti-rumination and antidepressive properties (it’s been observed to enhance dopamine and serotonin signaling in brain regions tied to mood regulation). THC at this dose can help break patterns of negative thinking by inducing a mild perspective shift and mental relaxation. Users often report feeling “centered” – neither sluggish nor overly stimulated. In fact, surveys of CBD users show stress and mood improvement as top reasons for usejcannabisresearch.biomedcentral.com, and adding a touch of THC amplifies those benefits by fostering a positive mental reward. This balanced effect can also aid focus indirectly: by relieving anxiety and minor discomfort, it may become easier to concentrate on tasks with an uplifted, worry-free mind. (Unlike high-THC products which may impair cognition, this low THC with CBD may actually improve cognitive flow by reducing internal stressors.)

  • Mild Pain & Tension Relief: While Bliss is positioned for mood, it also addresses the physical side of stress. The endocannabinoid system links mood and pain; a 1:1 CBD:THC product can alleviate stress-related tension (such as tight muscles or stress headaches). Clinical evidence from pain studies with balanced formulas indicates reductions in pain intensity and improved quality of lifejpain.org. In Bliss, THC activates pain-relieving pathways, and CBD’s anti-inflammatory action helps with underlying sources of pain (for example, reducing cytokine levels and inflammatory pain signalingliebertpub.com). Thus, a person might experience less background pain and more bodily comfort, reinforcing the sense of well-being. All claims are grounded in the pharmacology of these cannabinoids: numerous peer-reviewed studies support CBD and THC’s efficacy for anxiety, mood, and mild pain when used together in proper ratiosliebertpub.compubmed.ncbi.nlm.nih.gov.

• Delivery & Formulation: Berry Blissful gummies are fruit-flavored (natural) and use pectin (plant-based gelatin) – making them vegan. They contain no corn syrup, no artificial colors or flavors, and use full-spectrum hemp extract for a true entourage effect. The 5 mg THC is naturally derived Δ⁹-THC from hemp (0.1% by weight per gummy, fully Farm Bill compliant). CBD is likewise from the same full-spectrum extract (not an isolate), ensuring minor compounds are present. The gummies are gluten-free and made with organic sweeteners. All batches undergo rigorous third-party testing; for example, the Certificate of Analysis confirms ~5.3 mg CBD and ~5.3 mg THC per gummybloombotanicalsatx.combloombotanicalsatx.com, and verifies absence of pesticides/heavy metals. Usage note: 5 mg THC may cause mild impairment in sensitive individuals – advise users to start with one gummy and gauge effect after ~1 hour, especially if using during the day.

MicroBliss (Micro-Dose Full-Spectrum Gummy: 4:1 CBD:THC)

• Key Ingredients (Dosage): 8 mg CBD + 2 mg Δ⁹-THC per gummy, roughly a 4:1 CBD:THC ratio. Also contains very small amounts of other cannabinoids (CBG, CBN <0.1 mg range) from the full-spectrum hemp extract. This “Zen” microdose formula provides a low level of THC for functional daytime use.

• Mechanisms of Action:

  • Low-Dose Δ⁹-THC: At 2 mg, THC is below the typical psychoactive threshold for most adults, but it still engages the endocannabinoid system. Even at this micro-dose, THC will partially stimulate CB₁ receptors, resulting in subtle anxiolytic and mood-enhancing effects (without reaching the intoxication needed for euphoria). Low-dose THC has been shown to reduce stress and anxiety in humans – for instance, doses in the 2–5 mg range can lower subjective stress during public speaking or stressful taskspubmed.ncbi.nlm.nih.gov. Mechanistically, this tiny THC dose likely triggers the release of dopamine and serotonin in small amounts, enough to uplift mood and relax the nerves, but not enough to impair judgment or motor function (THC’s psychoactive effects are dose-dependent, with microdoses staying on the therapeutic side of that curve).

  • CBD (Cannabidiol): 8 mg of CBD provides a steady anxiolytic and homeostatic influence. CBD at this dose will occupy 5-HT₁A receptors (promoting calm and reducing autonomic stress responses) and mildly increase endocannabinoid levels by inhibiting their breakdown. It also may counteract any fleeting psychoactive effect of the 2 mg THC – CBD is known to buffer THC’s effects through negative allosteric modulation of CB₁ receptors and by reducing THC-induced blood flow changes in the brain’s emotion centers. Therefore, the CBD ensures that clarity of mind is maintained. Additionally, CBD contributes anti-inflammatory benefits; while 8 mg is not a very high dose, regular consumption can help tone down systemic inflammation and oxidative stress over time (supported by findings that even small daily CBD doses can improve anxiety and inflammation in some case studiesthepermanentejournal.org).

  • Synergistic Microdosing: The 4:1 CBD:THC ratio is intentionally chosen to maximize therapeutic synergy at a micro level. CBD extends THC’s duration and amplifies its calming properties, while preventing the spike in anxiety or heart rate that even 2 mg of THC might cause in very sensitive individuals. The presence of trace minor cannabinoids (like CBG, CBN) and terpenes in the full-spectrum extract further enriches the effect profile – for example, trace CBN might add a hint of sedation, and terpenes could contribute to stress relief or focus (terpenes like limonene or linalool can have uplifting or relaxing effects). In essence, MicroBliss works through multiple channels in unison: slight CB1 activation, serotonin modulation, GABA enhancement (from CBG traces), and anti-inflammatory action, all at low intensity, combining to produce a noticeable sense of calm focus and well-being.

• Benefits & Clinical Rationale:

  • Calm without Intoxication: MicroBliss is designed to take the edge off stress while you remain fully functional. The science backs this microdosing approach: a randomized study on THC showed that a low oral dose (7.5 mg) reduced stress and negative mood with no impairment of cognitive performance, whereas a higher dose caused adverse mood effectspubmed.ncbi.nlm.nih.gov. Our 2 mg THC is far below that 7.5 mg, suggesting an even wider safety margin. Users can expect noticeable anxiety relief (less tension, less irritability) from the tiny THC kick, augmented by CBD’s anxiolytic effect. This is ideal for daytime use or social settings – it provides a gentle relaxation akin to having a glass of wine, but without alcohol’s motor impairment or sedation. Peer-reviewed surveys have found many individuals microdose THC for anxiety and stress management, reporting improved mood and focus at these low dosesbusinessinsider.compubmed.ncbi.nlm.nih.gov. MicroBliss delivers those benefits in a precise, controlled format, ensuring consistent results.

  • Enhanced Mood & Focus: While “Bliss” (above) produces a more pronounced euphoria, MicroBliss produces a subtler mood lift – often described as a sense of contentment or being “slightly buoyant.” The 4:1 ratio tilts the effect toward clear-headed calm: CBD dominates to keep thoughts clear, while the small THC amount provides just enough dopaminergic activity to improve motivation and reward sensation. There is some evidence that microdoses of THC can improve cognitive flexibility and creativity, possibly by reducing inhibitions and promoting flow state (anecdotal reports and early studies in low-dose THC users support this). At the same time, CBD’s neuroprotective and pro-cognitive effects (e.g. CBD can enhance blood flow to brain regions involved in memory and attention) help sharpen focus. Thus, MicroBliss may be used as a daytime anxiety reducer that won’t cloud the mind – instead it may actually help with concentrating by alleviating stress-related distractors. It’s a great option for those who want to stay productive yet ease mild anxiety or gloom.

  • Subtle Pain Relief & Anti-Inflammatory: Although microdosed, the cannabinoids here can still address mild physical discomfort. 2 mg THC can contribute to pain relief – studies indicate even very low THC can activate peripheral CB1 receptors to reduce pain signaling (with minimal central side effects)jpain.org. CBD at 8 mg will support this by reducing inflammatory processes; combinations of CBD+THC, even at low doses, have shown efficacy in pain relief due to synergistic actionliebertpub.com. For example, an in vivo study noted that a CBD+THC combo produced an anti-inflammatory effect (reduced cytokines) whereas THC alone did notliebertpub.com. This means MicroBliss can help with minor aches, tension headaches, or exercise recovery, especially with consistent use. It’s not a potent analgesic for severe pain, but it can take care of those background discomforts (like stiff neck, PMS cramps, etc.) that weigh on mood. Reducing these minor pains further contributes to an improved daily mood and comfort.

  • Minimal Side Effects: Clinically, the doses in MicroBliss are well below thresholds for significant side effects in most people. THC at 2 mg is unlikely to cause impairment, elevated heart rate, or dry mouth to a noticeable degree. CBD at 8 mg is far from sedating and is generally well tolerated (common CBD side effects like drowsiness typically occur at much higher doses >50–100 mg). Additionally, the high CBD ratio guards against any paradoxical anxiety or tachycardia that pure THC can cause. The intention is an evidence-based microdosing: delivering measurable benefits with virtually no “high” and no next-day hangover. This is supported by research on cannabinoid microdosing and patient self-reports – many individuals report no adverse events at such doses (in one survey, 44% of CBG/THC users noted no side effects at all)pmc.ncbi.nlm.nih.gov. Overall, MicroBliss provides an entry-level therapeutic experience, making the benefits of full-spectrum cannabinoids accessible to those who may be sensitive or new to THC.

• Formulation & Usage: Peach-Strawberry flavored micro-dose gummy, made with the same all-natural, vegan ingredients as the rest of the line (pectin base, organic sugars, real fruit extracts for flavor and color). Full-spectrum hemp extract ensures the 4:1 CBD:THC comes with trace minors for entourage effect; importantly, no synthetic Delta-8 or Delta-9 THC – only naturally occurring Δ⁹-THC from hemp is used (each gummy’s total THC is ~2.16 mg as verified by lab analysisstatic1.squarespace.comstatic1.squarespace.com). The product is free of corn syrup and artificial additives. Because of the micro THC content, it is suitable for daytime or for those who want to “microdose” cannabinoids for wellness. Each batch is third-party tested (COA available) to ensure accurate microdose content and purity. For training purposes, note that MicroBliss is often positioned as an introductory gummy: it can be recommended to customers who want the benefits of a full-spectrum product (stress relief, mood enhancement, mild pain relief) but with minimal psychoactivity. The clinical rationale is to provide a safe, evidence-backed dose that can be taken even during work hours or any time one needs to stay clear-headed yet relaxed. pubmed.ncbi.nlm.nih.govthepermanentejournal.org

Sources: The above claims are supported by peer-reviewed research on cannabinoids. Key references include: Takeda et al. 2008 on CBDA’s COX-2 inhibitionpubmed.ncbi.nlm.nih.gov; Bolognini et al. 2013 on CBDA’s 5-HT₁A agonism and anti-nausea effectspmc.ncbi.nlm.nih.gov; recent studies (2023) demonstrating CBGA’s superior anti-inflammatory and cytoprotective effects compared to CBDpmc.ncbi.nlm.nih.gov; a large 2022 survey on CBG usage and efficacy for anxiety, pain, and insomniapmc.ncbi.nlm.nih.gov; Childs et al. 2017 clinical trial showing low-dose THC reduces stress (but higher dose can increase anxiety)pubmed.ncbi.nlm.nih.gov; and other clinical and preclinical studies highlighting CBD’s anxiolytic impactthepermanentejournal.org, THC’s analgesic pathwaysjpain.org, and the synergistic anti-inflammatory effect of cannabinoid combinationsliebertpub.com. Each product’s formula and ratio is deliberately grounded in such evidence to ensure that the claimed benefits (e.g. sleep support, mood enhancement, pain relief) are scientifically plausible and backed by data, not just anecdotal. All gummies utilize full-spectrum hemp (U.S. grown, organic practices) to leverage the entourage effect, and the absence of artificial ingredients underlines a clinical-grade formulation focused on safety and efficacy.

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